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Journal of Pharmacology And Experimental Therapeutics, Vol. 100, Issue 2, 119-127, 1950
Copyright © 1950 by American Society for Pharmacology and Experimental Therapeutics

PHARMACOLOGICAL AND TOXICOLOGICAL STUDIES ON 2-(N-p'-tolyl-N-(m'-HYDROXYPHENYL)-AMINOMETHYL)-IMIDAZOLINE (C-7337), A NEW ADRENERGIC BLOCKING AGENT

J. H. Trapold 1, M. R. Warren 1, and R. A. Woodbury 1

1 Division of Pharmacology, University of Tennessee, Memphis

1. 2-(N-p'-tolyl-N-(m'-hydroxyphenyl)-aminomethyl)-imidazoline (C-7337) has been shown to be a potent, relatively non-toxic adrenergic blocking agent following either intravenous or oral administration in dogs.

2. The duration of adrenergic blockade is shorter than that of Dibenamine but the blockade of either compound can be interrupted by ephedrine, amphetamine, Vonedrine, or Tuamine.

3. C-7337 in dose of 1 to 2 mgm. caused no alteration in the blood pressure response to 5 microgm. of histamine or 10 microgm. of acetylcholine.

4. The severe toxic signs following C-7337 administration appear to be mainly those of acute hypoglycemia and are readily controlled by glucose administration.

5. The hypoglycemia produced by insulin is prolonged by C-7337 administration and the hyperglycemic response to epinephrine is markedly reduced.

Submitted on May 17, 1950






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Copyright © 1950 by the American Society for Pharmacology and Experimental Therapeutics.