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Journal of Pharmacology And Experimental Therapeutics, Vol. 100, Issue 1, 94-99, 1950
Copyright © 1950 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF A NUMBER OF ARALKYLAMINES ON THE OXIDATION OF TYRAMINE BY AMINE OXIDASE

Edwin J. Fellows 1 and Frederick Bernheim 2

1 Temple University School of Medicine, Philadelphia, Pennsylvania
2 Duke University School of Medicine, Durham, North Carolina

In the present experiments determinations were made of the effect on motor activity in rats and on tyramine oxidation by amine oxidase of 39 benzylamine, heta-arylethylamine and aryl-2-aminopropane modifications. In many instances there was observed an excellent positive correlation between the effect of these derivatives on motor activity and amine oxidase inhibition. There were, however, notable exceptions which may be explained by permeability and distribution factors which can markedly influence in vivo results. In other experiments it was found that injection of several 3-amino-1-phenylbutane and 4-amino-1-phenylpentane derivatives in animals produced histopathologically demonstrable damage of the central nervous system. Since enzymatic data on these types of compounds were not available, it appeared desirable to include them in the present studies. All of these agents also exhibited a significant amine oxidase inhibitory effect.

Submitted on May 27, 1950






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Copyright © 1950 by the American Society for Pharmacology and Experimental Therapeutics.