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*PROCAINE
Journal of Pharmacology And Experimental Therapeutics, Vol. 100, Issue 1, 78-82, 1950
Copyright © 1950 by American Society for Pharmacology and Experimental Therapeutics

THE FATE OF INTRATHECAL PROCAINE AND THE SPINAL FLUID LEVEL REQUIRED FOR SURGICAL ANESTHESIA

Martin Helrich 1, E. M. Papper 2, Bernard B. Brodie 3, Marvin Fink 1, and E. A. Rovenstine 4

1 Department of Anesthesiology, New York University-Bellevue Medical Center, Research Service, Third (New York University) Medical Division, Goldwater Memorial Hospital, New York, N. Y.
2 Columbia-Presbyterian Medical Center, New York, N. Y.
3 National Heart Institute, National Institutes of Health, Bethesda, Md.
4 National Heart Institute, National Institutes of Health, Bethesda, M.d.

1. The decline of procaine concentration which limits the duration of spinal anesthesia is not due to chemical breakdown of the drug in the spinal fluid, but to absorption into the systemic circulation where it is metabolized to p-aminobenzoic acid and diethylaminoethanol.

2. The concentrations of procaine at various levels of the subarachnoid space decline at the same rate.

3. There is a critical concentration of procaine, about 0.2 mgm. per ml., which is necessary for sensory anesthesia.

Submitted on May 25, 1950




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