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1 Departments of Pharmacology and Biochemistry, Baylor University College of Medicine, Houston 5, Texas
Mercurial diuretics when administered intravenously reversibly inhibit the succinic dehydrogenase system of dog and rat kidney cortices. Maximal inhibition occurs in the dog kidney during peak mercurial diuresis and recovery of enzyme activity is coincidental with recovery from diuresis. The administration of 2,3-dimercaptopropanol prior to removal of the kidney completely abolishes the effect of the mercurial diuretic on the enzyme system. When compared with p-chloromercuribenzoate, a potent inhibitor of enzymes containing sulfhydryl groups essential to activity, mercurial diuretics are approximately one-half as active for producing inhibition of the succinic dehydrogenase system.
Submitted on June 6, 1950
This article has been cited by other articles:
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  C. T. RAY Mercurial Diuretics: Their Mechanism of Action and Application Arch Intern Med, December 1, 1958; 102(6): 1016 - 1023. [Abstract] [PDF]
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 A. W. Sexton and R. L. Russell Succinic Dehydrogenase Activity in the Goldfish Gill Science, March 4, 1955; 121(3140): 342 - 343. [PDF]
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J. Grossman MERCURIAL DIURESIS Arch Intern Med, October 1, 1953; 92(4): 459 - 463. [Abstract] [PDF]
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K. K. Mustakallio and A. Telkka Histochemical Localization of the Mercurial Inhibition of Succinic Dehydrogenase in Rat Kidney Science, September 18, 1953; 118(3064): 320 - 321. [PDF]
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