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Journal of Pharmacology And Experimental Therapeutics, Vol. 100, Issue 1, 1-13, 1950
Copyright © 1950 by American Society for Pharmacology and Experimental Therapeutics

PAIN RELIEF WITH HYPNOTIC DOSES OF BARBITURATES AND A HYPOTHESIS

Arthur S. Keats 1 and Henry K. Beecher 1

1 Anesthesia Laboratory of the Harvard Medical School at the Massachusetts General Hospital, Boston, Massachusetts

1. Hypnotic doses of pentobarbital sodium intravenously relieved what has been called postoperative pain in 50 per cent of patients, in contrast to 20 per cent with saline and 80 per cent with morphine (a total of 178 patients was studied).

2. The pain experience of man consists of both perception of painful stimuli and the psychic modification of these stimuli.

3. A hypothesis is presented to explain the analgesic properties of pentobarbital by depression of the internuncial spread of pain impulses in the brain and inhibition of the psychic phase of pain experience. An analogy to prefrontal lobotomy is drawn.

Submitted on April 5, 1950




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Copyright © 1950 by the American Society for Pharmacology and Experimental Therapeutics.