LOCAL HEMOSTATIC PROPERTIES OF COTARNINE AND SOME OTHER AGENTS

¹ From the Pharmacological Laboratory, Western Reserve University, Cleveland, Ohio

1. Epinephrin (1:1000 and powdered tablets containing 1 mgm.) acts as an efficient hemostatic for small and superficial wounds. The effects are temporary and somewhat variable. It seems to be ineffective for stopping venous hemorrhage.

2. Stypticin and styptol (10 per cent solutions and dry powders) are inefficient as local hemostatics, even after long periods of and repeated application. In fact, hemorrhage tends to be somewhat aggravated after the application of these agents, and styptol is irritating.

3. Epinephrin (1:1000) is a prompt and effective peripheral vasoconstrictor in the rabbit's ear, while styptol and stypticin (10 per cent solutions) are inactive and inefficient. Styptol and stypticin produce relaxation of frog's vessels, and stypticin of uterine vessels.

4. The following agents do not appear to act either as local hemostatics or peripheral vasoconstrictors; sodium phthalate 10 per cent, lung extract 100 per cent, kephalin 5 per cent and hydrastinine hydrochloride 10 per cent. With the exception of the phthalate, however, final conclusions are reserved until experiments with these drugs have been extended.