Fig. 13.   Comparative effects of prenatal exposure to nicotine by infusion, or cocaine by injection (Slotkin et al., 1987c; Seidler and Slotkin, 1993). Although both nicotine and cocaine elicit evidence of cell damage (elevated ornithine decarboxylase, ODC), the effect of nicotine is more persistent. Nicotine (Nic), but not cocaine (Coc), produces deficits in cell number, as evidenced by reduced DNA content. ANOVA, analysis of variance.